As the wagon train moves through Sioux territory, a man named Marshall asks for help in finding his daughter, Ruth, who apparently was taken by Indians following a raid eleven years ago. The girl would now be 19 years old. Flint McCullough goes in search of the girl, is injured in an ambush by a lone Indian, and is treated by a blue-eyed white woman living with four wolves. The woman communicates only through sign-language and is held in reverence by the local Sioux. Meanwhile the Indian who ambushed Flint and was wounded in the process reports back to his father, Red Cloud. Red Cloud learns that the ""Woman Who Lives with Wolves"" is treating a white man and orders Flint to be brought to his camp for possible punishment. The Wolf Woman intervenes and has Flint returned to the wagon train along with a book which bears the name ""Ruth Marshall"" on its flyleaf.